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KMID : 0613820110210111586
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Journal of Life Science
2011 Volume.21 No. 11 p.1586 ~ p.1591
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Anti-Obesity Effect of Crataegus Fructus Extract from Chinese Cultivation
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Gal Sang-Wan
Choi Young-Jae
Cho Soo-Jeong
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Abstract
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This study was carried out to evaluate the antiobesity effects of Crataegus fructus in 3T3-L1 adipocytes and mice fed a high fat diet (high fat 45% cal). The inhibitory effect of methanol extract from Crataegus fructus on lipid accumulation in 3T3-L1 adipocytes was quantified using Oil red O staining. Compared with the control, lipid accumulation was significantly decreased by 10-25% with treatment with Crataegus fructus extract at a concentration of 600-2,000 ug/ml. Three-week old ICR mice (n=24) were randomly divided into four groups (T0: normal diet, T1: high fat diet, T2: high fat diet and 50 ug of Crataegus fructus extract, T3: high fat diet and 100 ug of Crataegus fructus extract) and were fed an experimental diet for 5 weeks. At the end of the experiment, body weight gain in the T1 group (3.9±0.24 g) was higher than that in the T0 group (2.56±0.14 g), while body weight gain in the T2 (3.02±0.25 g) and T3 (2.58±0.16 g) groups was significantly reduced as compared with that of the T1 group. Moreover, liver weight in the T1 (4.8±0.17 g) and T2 (4.8±0.16 g) groups was significantly higher than that of the T0 (4.05±0.16 g) and T3 (4.57±0.10 g) groups, while kidney weight was significantly lower than that of the T0 and T3 groups (p<0.05). The levels of total cholesterol and triglyceride in serum in the T2 and T3 groups were significantly decreased compared to the T1 group. These results suggest that Crataegus fructus can be used as functional materials in food and medicine.
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KEYWORD
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Crataegus fructus, antiobesity, 3T3-L1 adipocytes, high fat diet
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